Báo cáo khoa học: Glycogen-rich clear cell carcinoma of the breast

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Glycogen-rich clear cell carcinoma of the breast
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Báo cáo khoa học: "Glycogen-rich clear cell carcinoma of the breast"World Journal of Surgical Oncology BioMed Central Open AccessCase reportGlycogen-rich clear cell carcinoma of the breastChristos Markopoulos*, Dimitris Mantas, T Philipidis, Efstatios Kouskos,Zoi Antonopoulou, ML Hatzinikolaou and Helen GogasAddress: Breast Unit, 2nd Propedeutic Department of Surgery, Athens University Medical School, GreeceEmail: Christos Markopoulos* - cmarkop@hol.gr; Dimitris Mantas - dvmantas@med.uoa.gr; T Philipidis - philipidis@otenet.gr;Efstatios Kouskos - skouskos@hotmail.com; Zoi Antonopoulou - zoianton@otenet.gr; ML Hatzinikolaou - mlhatzinikolaou@med.uoa.gr;Helen Gogas - hgogas@med.uoa.gr* Corresponding authorPublished: 29 April 2008 Received: 26 November 2007 Accepted: 29 April 2008World Journal of Surgical Oncology 2008, 6:44 doi:10.1186/1477-7819-6-44This article is available from: http://www.wjso.com/content/6/1/44© 2008 Markopoulos et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Glycogen-rich carcinoma of the breast is a rare histological subtype of breast cancer, usually reported to have poor prognosis. Case presentation: We present the case of a 59-year-old woman who underwent a mastectomy for a 3.5 cm clinically palpable left breast carcinoma, originally diagnosed as fibroadenoma on a screening mammogram four years before presentation. Diagnosis of clear cell carcinoma was based on certain histological characteristics of the tumour and immunohistochemical analysis (PAS staining, keratins AE1/AE3, EMA, cytokeratin 7, cytokeratin 20, melanosomes, vimentin, Chromogranin, Synaptophysin, S-100, SMA). No lymph node metastasis was found and as the tumour was ER positive and PgR negative, patient was treated only with an aromatase inhibitor upfront and remains free of disease 48 months now since operation. Conclusion: Glycogen-rich clear cell carcinoma of the breast is a rare tumor, its clinical behavior reported to be rather aggressive so far, might varies depending on special characteristics such as low grade and strongly positive ER expression ing tumour of her left breast, originally considered asBackgroundGlycogen-rich clear cell carcinoma is a rare neoplasm of fibroadenoma, but which proved to be a 3.5 cm glycogen-the breast, with an incidence of between 1.4% and 3% of rich clear cell carcinoma without lymph node involve-all breast cancers [1,2]. The tumour has distinct morphol- ment, four years later.ogy, different from that of common breast cancers. Itshares common characteristics with clear cell carcinomas Case presentationof the lung, endometrium, cervix, ovary, kidneys and sali- A 59-year-old Caucasian woman presented with a breastvary glands [3]. Glycogen-rich clear cell carcinomas are mass in the upper outer quadrant of her left breast. Shemembers of a heterogeneous group of neoplasms, includ- noticed the lump on self-examination a few monthsing signet-ring, secretory and lipid-rich carcinomas of the before presenting to our out-patient clinic. The lesion wasbreast [4]. In general, clear cell breast carcinoma tends to mobile, with no evidence of dermal invasion and axillaryfollow an aggressive clinical course [5]. However, we lymph nodes were not palpable. A 3.5 cm lobulated, cir-report the case of a 59-year-old woman with a slow grow- cumscribed mass was shown on her recent mammogram, Page 1 of 4 (page number not for citation purposes)World Journal of Surgical Onc ...