Báo cáo khoa học: Glycoprotein Ib-mediated platelet activation A signalling pathway triggered by thrombin
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Platelet activation by thrombin plays a major role inthe development of haemostasis and thrombosis. Thrombinactivates human platelets by cleaving the N-terminal regionof G-protein-coupled protease-activated receptors (PARs).On the other hand, the platelet membrane glycoproteinGPIb acts as a thrombin-binding site and promotes plateletactivation by low thrombin concentrations.We present herenew evidence in favour of a thrombin receptor function forGPIb. We have selected conditions in which thrombin–GPIb interactions were enhanced by thrombin immobiliza-tion....
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Báo cáo khoa học: Glycoprotein Ib-mediated platelet activation A signalling pathway triggered by thrombin
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Báo cáo khoa học: Glycoprotein Ib-mediated platelet activation A signalling pathway triggered by thrombin
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