Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
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Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a proteinaseinvolved in the remodelling of extracellular matrix and the cleavage of anumber of substrates. MT1-MMP is synthesized as a zymogen that requiresintracellular post-translational cleavage to gain biological activity. Furin,a member of the pro-protein convertase family, has been implicated in theproteolytic removal of the MT1-MMP prodomain sequence.
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Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
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