Báo cáo khoa học: Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists
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Thrombopoietin is the primary regulator of platelet production. We exploi-ted two naturally occurring miniproteins of the inhibitor cystine knot fam-ily as stable and rigid scaffolds for the incorporation of peptide sequencesthat have been shown to act as high-affinity thrombopoietin antagonists.Several miniproteins that antagonistically block thrombopoietin-mediatedreceptor activation were identified using a microscale reporter assay.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists
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