Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses
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A search has been initiated for lead inhibitors of the non-structural protein 3 (NS3)-associated NTPase/helicaseactivities of hepatitis C virus,the related West Nile virus,Japanese encephalitis virus and the human mitochondrialSuv3 enzyme. Random screening of a broad range of unre-lated low-molecular mass compounds,employing bothRNA and DNA substrates, revealed that 4,5,6,7-tetra-bromobenzotriazole (TBBT) hitherto known as a potenthighly selective inhibitor of protein kinase 2,is a goodinhibitor of the helicase,but not NTPase,activity of hepa-titis C virus NTPase/helicase. ...
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Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses
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Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses
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