Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer's amyloid b-peptide
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Metal binding to the amyloidb-peptide is suggested to be involved in thepathogenesis of Alzheimer’s disease. We used high-resolution NMR tostudy zinc binding to amyloid b-peptide 1–40 at physiologic pH. Metalbinding induces a structural change in the peptide, which is in chemicalexchange on an intermediate rate, between the apo-form and the holo-form,with respect to the NMR timescale.
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Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer’s amyloid b-peptide
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Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer’s amyloid b-peptide
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