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Báo cáo khoa học: HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling

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HIP/PAP is a C-type lectin overexpressed in hepatocel-lular carcinoma (HCC). Pleiotropic biological activitieshave been ascribed to this protein, but little is knownabout the function of HIP/PAP in the liver. In thisstudy, therefore, we searched for proteins interacting withHIP/PAP by screening a HCC cDNA expression library.We have identified the RIIa regulatory subunit ofcAMP-dependent protein kinase (PKA) as a partner ofHIP/PAP. HIP/PAP and RIIa were coimmunoprecipi-tated in HIP/PAP expressing cells. ...
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Báo cáo khoa học: HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling

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