Báo cáo khoa học: Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases
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After the successful cloning of the first gene for a polyglutamine disease in1991, the expanded polyglutamine tract in the nine polyglutamine diseaseproteins became an obvious therapeutic target. Early hypotheses were thatmisfolded, precipitated protein could be a universal pathogenic mechanism.However, new data are accumulating on Huntington’s disease and otherpolyglutamine diseases that appear to contradict the toxic aggregatehypothesis.
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Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases
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Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases
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