Báo cáo khoa học: Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production – a correction using glutathione depletion
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The production of H2O2 by isolated mitochondria is frequently used as ameasure of mitochondrial superoxide formation. Matrix superoxide dismu-tase quantitatively converts matrix superoxide to H2O2. However, matrixenzymes such as the glutathione peroxidases can consume H2O2and com-pete with efflux of H2O2, causing an underestimation of superoxide produc-tion.
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Báo cáo khoa học: Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production – a correction using glutathione depletion
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production – a correction using glutathione depletion
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