Báo cáo khoa học: Identification and expression of the first nonmammalian amyloid-b precursor-like protein APLP2 in the amphibian Xenopus laevis
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The Alzheimer’s disease-linked amyloid-bprecursor pro-tein (APP) belongs to a superfamily of proteins, whichalso comprises the amyloid-b precursor-like proteins,APLP1 and APLP2. Whereas APP has been identified inboth lower and higher vertebrates, thus far, APLP1 and 2have been characterized only in human and rodents. Herewe identify the first nonmammalian APLP2 protein in theSouth African claw-toed frogXenopus laevis.The identitybetween the Xenopusand mammalian APLP2 proteinsis 75%, with the highest degree of conservation in anumber of amino-terminal regions, the transmembranedomain and the cytoplasmic tail....
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Báo cáo khoa học: Identification and expression of the first nonmammalian amyloid-b precursor-like protein APLP2 in the amphibian Xenopus laevis
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Identification and expression of the first nonmammalian amyloid-b precursor-like protein APLP2 in the amphibian Xenopus laevis
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