Báo cáo khoa học: Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection
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To generate human antibodies against CXCR4, a seven-transmembrane chemokine receptor and a principalcoreceptor forHIV-1, several roundsofPathfinder andStep-back selection from a large phage display antibody librarywere performed on Jurkat cells. A mAb against CXCR4 orbiotinyated phage antibodies were used as guide molecules.Over 100 pan-Jurkat-cell-positive antibodies were charac-terized, but none were CXCR4 specific.
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Báo cáo khoa học: Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection
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