Báo cáo khoa học: Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in b-tubulin
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G-protein-coupled receptor kinase 2 (GRK2) is known tospecifically phosphorylate the agonist-bound forms ofG-protein-coupled receptors (GPCRs). This strict specificityis due at least partly to activation of GRK2 by agonist-bound GPCRs, in which basic residues in intracellularregions adjacent to transmembrane segments are thought tobe involved. Tubulin was found to be phosphorylated byGRK2, but it remains unknown if tubulin can also serve asboth a substrate and an activator for GRK2.
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Báo cáo khoa học: Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in b-tubulin
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Báo cáo khoa học: Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in b-tubulin
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