Báo cáo khóa học: Inactivation of copper-containing amine oxidases by turnover products
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For bovine serum amine oxidase, two different mechanismsof substrate-induced inactivation have been proposed. Oneconsists of a slow oxidation by H2O2of a conserved residuein the reduced enzyme after the fast turnover phase [Pietr-angeli, P., Nocera, S., Fattibene, P., Wang, X.T., Mondovı`,B. &Morpurgo, L. (2000)Biochem. Biophys. Res. Commun.267, 174–178] and the other of the oxidation byH2O2of thedihydrobenzoxazole in equilibrium with the product Schiffbase, during the catalytic cycle [Lee, Y., Shepard, E., Smith,J., Dooley, D.M. & Sayre, L.M. (2001)Biochemistry40,822–829]. ...
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Báo cáo khóa học: Inactivation of copper-containing amine oxidases by turnover products
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Báo cáo khóa học: Inactivation of copper-containing amine oxidases by turnover products
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