Báo cáo khoa học: Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P) + -dependent malic enzyme Functional roles of the nucleotide binding site Lys346
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Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD-ME)is a malic enzyme isoform with dual cofactor specificity, ATP inhibitionand substrate cooperativity. The determinant of ATP inhibition in malicenzyme isoforms has not yet been identified. Sequence alignment of nucleo-tide-binding sites of ME isoforms revealed that Lys346 is conserveduniquely in m-NAD-ME.
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Báo cáo khoa học: Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P) + -dependent malic enzyme Functional roles of the nucleotide binding site Lys346
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P) + -dependent malic enzyme Functional roles of the nucleotide binding site Lys346
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