Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration
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Fibrillization ofa-synuclein (a-Syn) is closely associated with the formationof Lewy bodies in neurons and dopamine (DA) is a potent inhibitor forthe process, which is implicated in the causative pathogenesis of Parkin-son’s disease (PD). To elucidate any molecular mechanism that may havebiological relevance, we tested the inhibitory abilities of DA and severalanalogs including chemically synthetic and natural polyphenols in vitro.
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Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration
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