Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A
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The cAMP-dependent protein kinase (PKA) signalingpathway plays a major role in a number of pathophysio-logical conditions. However, there have been conflictingevidences regarding the action of cAMP/PKA on nuclearfactor-jB(NF-jB). Inthis study,wehaveexplored the effectof cAMP/PKA on NF-jBactivity and determined itsmolecular mechanism. PKA activating agents or expressionof thecatalyticsubunitofPKA(PKAc) inhibitedtheNF-jB-dependent reporter gene expression induced by tumor nec-rosis factora(TNFa). ...
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Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A
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Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A
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