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Brain serine racemase contains pyridoxal phosphate as a prosthetic groupand is known to become activated by divalent cations such as Ca2+andMg2+, as well as by ATP and ADP. In vivo, brain serine racemase is alsoactivated by a multi-PSD-95⁄discs large⁄ZO-1 (PDZ) domain glutamatereceptor interacting protein (GRIP) that is usually coupled to the GluR2⁄3subunits of the a-amino-3-hydroxy-5-methylisoxazole-4-propionic acidCa2+channel.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP
