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The effect of insulin on cancer metastatic potential wasstudied in a human hepatocarcinoma cell line, H7721. Celladhesion to human umbilical vein endothelial cells(HUVECs) and lamininaswell as chemotactic cellmigrationand invasion were selected as the indices of metastasis-related phenotypes for assessment of metastatic potentialex vivo. The results indicated that insulin enhanced all ofthese metastasis-related phenotypes. After the cells weretreated with specific inhibitor of PI3K (LY294002) ortransfected with antisense cDNA of PKB (AS-PKB), all ofthe above phenotypes were attenuated, and they could notbe significantly stimulated by insulin, indicating that theinsulin effect onmetastatic potential was mediated by PI3Kand PKB. ...
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Insulin/protein kinase B signalling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell line
