Báo cáo khoa học: Interaction of human stefin B in the prefibrillar oligomeric form with membranes Correlation with cellular toxicity
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Protein aggregation is central to most neurodegenerative diseases, as shownby familial case studies and by animal models. A modified ‘amyloid cas-cade’ hypothesis for Alzheimer’s disease states that prefibrillar oligomers,also called amyloid-b-derived diffusible ligands or globular oligomers, arethe responsible toxic agent. It has been proposed that these oligomeric spe-cies, as shown for amyloid-b, b2-microglobulin or prion fragments, exerttoxicity by forming pores in membranes, initiating a cascade of detrimentalevents for the cell. ...
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Báo cáo khoa học: Interaction of human stefin B in the prefibrillar oligomeric form with membranes Correlation with cellular toxicity
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Báo cáo khoa học: Interaction of human stefin B in the prefibrillar oligomeric form with membranes Correlation with cellular toxicity
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