Báo cáo khoa học: K8 and K12 are biotinylated in human histone H4
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Folding of DNA into chromatin is mediated by binding tohistones such as H4; association of DNA with histones isregulated by covalent histone modifications,e.g. acetylation,methylation,andbiotinylation.We sought to identifyamino-acid residues that are biotinylated in histone H4,and todetermine whether acetylation and methylation of histonesaffect biotinylation. Synthetic peptides spanning fragmentsof human histone H4 were biotinylated enzymatically usingbiotinidase. Peptide-bound biotin was probed with strept-avidin–peroxidase....
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Báo cáo khoa học: K8 and K12 are biotinylated in human histone H4
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Báo cáo khoa học: K8 and K12 are biotinylated in human histone H4
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