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Báo cáo khoa học: KIPase activity is a novel caspase-like activity associated with cell proliferation

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Anovel caspase-like activity, which is directly regulatedwithcell proliferation is a candidate to regulate the abundance ofthe cyclin-dependent kinase inhibitor, p27KIP1, in humanlymphoid cells.This activity, whichwe termKIPase activity,can also cleave a subset of caspase substrates.Here wedemonstrate thatKIPase is anovel enzymedistinct fromanyof the previously characterized human caspases.We showthatKIPase is active in a variety of cell lineages, its activity isassociated with the proliferation of the human T-cell line,Jurkat, and is not inhibited by the broad spectrum caspaseinhibitor z-VAD-fmk....
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Báo cáo khoa học: KIPase activity is a novel caspase-like activity associated with cell proliferation

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