Báo cáo khoa học: Ligand-specific dose–response of heterologously expressed olfactory receptors
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Primary olfactory neuronal cultures exposed to odorantstimulation have previously exhibited concentration-relatedeffects in terms of intracellular cAMP levels and adenylatecyclase activity [Ronnett, G.V., Parfitt, D.J., Hester, L.D. &Snyder, S.H. (1991)PNAS88, 2366–2369].Maximal sti-mulation occurred for intermediate concentrations, whereasAC activity declined for both low and high odorant con-centrations.We suspected that this behavior might beascribed to the intrinsic response of the first molecularspecies concerned by odorant detection, i.e. the olfactoryreceptor itself....
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Báo cáo khoa học: Ligand-specific dose–response of heterologously expressed olfactory receptors
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Báo cáo khoa học: Ligand-specific dose–response of heterologously expressed olfactory receptors
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