Báo cáo khoa học: Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis
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Human glutamate carboxypeptidase II [GCPII (EC 3.4.17.21)] is recog-nized as a promising pharmacological target for the treatment and imagingof various pathologies, including neurological disorders and prostate can-cer. Recently reported crystal structures of GCPII provide structuralinsight into the organization of the substrate binding cavity and highlightresidues implicated in substrate⁄inhibitor binding in the S1¢ site of theenzyme.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis
Tìm kiếm theo từ khóa liên quan:
Report medicine traditional medicine scientific reports Structural biochemistry oxidation bacteriaTài liệu liên quan:
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