Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides
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We report a detailed kinetic investigation of the aminoglycosides neomycinB and neamine as inhibitors of the lethal factor protease fromBacillusanthracis. Both inhibitors display a mixed-type, noncompetitive kinetic pat-tern, which suggests the existence of multiple enzyme–inhibitor bindingsites or the involvement of multiple structural binding modes at the samesite.
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Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides
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