Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase
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GE23077, a novel microbial metabolite recently isolatedfrom Actinomadurasp. culture media, is a potent andselective inhibitor of bacterial RNApolymerase (RNAP). ItinhibitsGram-positive (Bacillus subtilis) andGram-negative(Escherichia coli)RNAPs with IC50values (i.e. the concen-tration at which the enzyme activity is inhibited by 50%) inthe 10)8Mrange, whereas it is not active onE. coliDNApolymerase or on eukaryotic (wheat germ) RNAP II (IC50values10)4Min both cases).
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase
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