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Phân tích tư tưởng của nhân dân qua đoạn thơ: Những người vợ nhớ chồng… Những cuộc đời đã hóa sông núi ta trong Đất nước của Nguyễn Khoa Điềm
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NMR spectroscopy and X-ray crystallography have provi-ded important insight into structural features of phenyl-alanine hydroxylase (PAH) and tyrosine hydroxylase (TH).Nevertheless, significant problems such as the substratespecificity of PAHand the different susceptibility of THto feedback inhibition by L-3,4-dihydroxyphenylalanine(L-DOPA) compared with dopamine (DA) remain unre-solved. Based on the crystal structures 5pah for PAHand2toh for TH(Protein Data Bank), we have used moleculardocking to model the binding of 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) and the substrates phenylalanineand tyrosine to the catalytic domains of PAHand TH....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase
