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The transient receptor potential channel vanilloid receptorsubunit 1 (TRPV1) is amolecular integrator of physical andchemical stimuli in the peripheral nociceptor terminals.TRPV1 is an ionotropic channel that plays a critical role inboth thermal nociception and inflammatoryhyperalgesia.Structure–function relationships are providing fundamentalinsights of the modular architecture of this neuronal recep-tor. As a result, the molecular determinants that endowTRPV1 with its physiological properties, namely activationbyheat, potentiation byextracellular acidic pH, and inter-action with vanilloid-like compounds, as well as its per-meation properties are being unveiled....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Molecular architecture of the vanilloid receptor Insights for drug design
