Báo cáo khoa học: Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae
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Oxysterol binding protein (OSBP) and its homologs have been shown toregulate lipid metabolism and vesicular transport. However, the exactmolecular function of individual OSBP homologs remains uncharacterized.Here we demonstrate that the yeast OSBP homolog, Osh6p, bound phos-phatidic acid and phosphoinositides via its N-terminal half containing theconserved OSBP-related domain (ORD). Using a green fluorescent proteinfusion chimera, Osh6p was found to localize to the cytosol and patch-likeor punctate structures in the vicinity of the plasma membrane....
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Báo cáo khoa học: Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae
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