Báo cáo khoa học: Monitoring ligand-mediated nuclear receptor–coregulator interactions by noncovalent mass spectrometry
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Retinoid receptors are ligand-dependent transcriptionfactors belonging to the nuclear receptor superfamily.Retinoic acid (RARa, b, c) and retinoid X (RXRa, b, c)receptors mediate the retinoid/rexinoid signal to thetranscriptional machineries by interacting at the first levelwith coactivators or corepressors, which leads to therecruitment of enzymatically active noncovalent com-plexes at target gene promoters. It has been shown thatthe interaction of corepressors with nuclear receptors in-volves conserved LXXI/HIXXXI/L consensus sequencestermed corepressor nuclear receptor (CoRNR) boxes....
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Báo cáo khoa học: Monitoring ligand-mediated nuclear receptor–coregulator interactions by noncovalent mass spectrometry
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Báo cáo khoa học: Monitoring ligand-mediated nuclear receptor–coregulator interactions by noncovalent mass spectrometry
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