Báo cáo khoa học: Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps – first come, first served?
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Multidrug resistance is a major challenge in the therapy of cancer andpathogenic fungal infections. More than three decades ago, P-glycoproteinwas the first identified multidrug transporter. It has been studied exten-sively at the genetic and biochemical levels ever since. Pdr5, the most abun-dant ATP-binding cassette transporter in Saccharomyces cerevisiae,ishighly homologous to azole-resistance-mediating multidrug transporters infungal pathogens, and a focus of clinical drug resistance research. ...
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Báo cáo khoa học: Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps – first come, first served?
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Báo cáo khoa học: Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps – first come, first served?
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