Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations
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Experimental autoimmune encephalomyelitis can beinduced in susceptible animals by immunodominant deter-minants of myelin basic protein (MBP). To characterize themolecular features of antigenic sites important for designingexperimental autoimmune encephalomyelitis suppressingmolecules, we report structural studies, based on NMRexperimental data in conjunction with molecular dynamicsimulations, of the potent linear dodecapeptide epitope ofguinea pig MBP, Gln74-Lys75-Ser76-Gln77-Arg78-Ser79-Gln80-Asp81-Glu82-Asn83-Pro84-Val85 [MBP(74–85)],and its antagonist analogue Ala81MBP(74–85)....
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations
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