Báo cáo khoa học: Nucleocytoplasmic shuttling of STAT transcription factors Thomas Meyer and Uwe Vinkemeier
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The signal transducer and activator of transcription (STAT)proteins have initiallybeendescribedas cytoplasmicproteinsthat enter the nucleus only after cytokine treatment of cells.Contrary to this assumption, it was demonstrated thatSTATs are constantly shuttling between nucleus and cyto-plasm irrespective of cytokine stimulation. This happensboth via carrier-dependent as well as carrier-independenttransportation. Moreover, it was also recognized that cyto-kine stimulation triggers nuclear retention of dimericSTATs, rather than affecting the rate of nuclear import. ...
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Báo cáo khoa học: Nucleocytoplasmic shuttling of STAT transcription factors Thomas Meyer and Uwe Vinkemeier
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Báo cáo khoa học: Nucleocytoplasmic shuttling of STAT transcription factors Thomas Meyer and Uwe Vinkemeier
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