Báo cáo khóa học: Photoaffinity labelling of the Human GM2-activator protein Mechanistic insight into ganglioside GM2 degradation
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The GM2-activator protein (GM2AP) is an essentialcofactor for the degradation of ganglioside GM2 by lyso-somal b-hexosaminidase A. It mediates the interactionbetween the water-soluble exohydrolase and its membrane-bound substrate at the lipid–water interphase. Inheriteddefects in the gene encoding this glycoprotein result ina fatalneurological storage disorder, the AB variant of GM2-gangliosidosis. To elucidate the mode of action of this gly-coprotein cofactor, we synthesized the two photoaffinitylabels [14C]C3-TPD-GM2 and [14C]C7-TPD-GM2. ...
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Báo cáo khóa học: Photoaffinity labelling of the Human GM2-activator protein Mechanistic insight into ganglioside GM2 degradation
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Báo cáo khóa học: Photoaffinity labelling of the Human GM2-activator protein Mechanistic insight into ganglioside GM2 degradation
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