Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins
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The high specificity ofa-conotoxins for different neuronalnicotinic acetylcholine receptors makes them importantprobes for dissecting receptor subtype selectivity. Newsequences continue to expand the diversity and utility ofthe pool of available a-conotoxins. Their identificationandcharacterizationdependonasuiteoftechniqueswith increasing emphasis on mass spectrometry and micro-scale chromatography, which have benefited from recentadvances in resolution and capability. Rigorous physico-chemical analysis together with synthetic peptide chemistryis a prerequisite for detailed conformational analysis and toprovide sufficient quantities ofa-conotoxins for activityassessment and structure–activity relationship studies....
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Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins
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Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins
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