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The mechanism by which the CXC chemokine platelet fac-tor 4 (PF-4) inhibits endothelial cell proliferation is unclear.The heparin-binding domains of PF-4 have been reported toprevent vascular endothelial growth factor 165 (VEGF165)andfibroblast growth factor 2 (FGF2) frominteractingwiththeir receptors. However, other studies have suggested thatPF-4 acts via heparin-binding independent interactions.Here, we compared the effects of PF-4 on the signallingevents involved in the proliferation induced by VEGF165,which binds heparin, and by VEGF121, which does not....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms
