Báo cáo khoa học: Possible binding site for paclitaxel at microtubule pores
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Taxanes and other microtubule-stabilizing agents comprise an importantclass of anticancer drugs. It is well known that taxanes act by binding tob-tubulin on the lumenal side of microtubules. However, experimental evi-dence obtained in recent years led to the hypothesis of an external site onthe microtubule wall to which taxanes and other microtubule-stabilizingagents could bind before being internalized to their lumenal site.
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Báo cáo khoa học: Possible binding site for paclitaxel at microtubule pores
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Báo cáo khoa học: Possible binding site for paclitaxel at microtubule pores
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