Báo cáo khoa học: Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system
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We report the cloning, expression, pharmacological char-acterization and tissue distribution of a melanocortin (MC)receptor gene in a shark, the spiny dogfish (Squalus acanth-ias) (Sac). Phylogenetic analysis showed that this receptor isanorthologof theMC4 subtype, sharing71%overall aminoacid identity with the human (Hsa) MC4 receptor. Whenexpressedandcharacterizedbyradioligandbindingassay forthe natural MSH (melanocyte-stimulating hormone) pep-tides a-, b-, and c-MSH, the SacMC4 receptor showedpharmacological properties very similar to the HsaMC4receptor. ...
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Báo cáo khoa học: Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system
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Báo cáo khoa học: Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system
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