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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control

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10.10.2023

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General and simple principles are identified that govern signal transduc-tion. The effects of kinase and phosphatase inhibition on a MAP kinasepathway are first examinedin silico. Quantitative measures for the controlof signal amplitude, duration and integral strength are introduced. We thenidentify and prove new principles, such that total control on signal ampli-tude and on final signal strength must amount to zero, and total controlon signal duration and on integral signal intensity must equal)1. Collec-tively, kinases control amplitudes more than duration, whereas phospha-tases tend to control both. ...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control

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