Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation
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The glyoxalase pathway ofLeishmania infantumwas kinetically character-ized as a trypanothione-dependent system. Using time course analysisbased on parameter fitting with a genetic algorithm, kinetic parameterswere estimated for both enzymes, with trypanothione derived substrates. AKmof 0.253 mmand aVof 0.21lmolÆmin)1Æmg)1for glyoxalase I, and aKmof 0.098 mmand aVof 0.18lmolÆmin)1Æmg)1for glyoxalase II, wereobtained.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation
Tìm kiếm theo từ khóa liên quan:
Report medicine traditional medicine scientific reports Structural biochemistry oxidation bacteriaTài liệu liên quan:
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