Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling
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The Rho-like GTPase Rac regulates distinct actin cytoskeleton changesrequired for adhesion, migration and invasion of cells. Tiam1 specificallyactivates Rac, and Rac has been shown to affect several signaling pathwaysin a partly cell-type-specific manner. Recently, we demonstrated that Racactivation inhibits Matrigel invasion of human carcinoma cells by tran-scriptional upregulation of tissue inhibitor of metalloproteinase-1.
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Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling
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Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling
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