Báo cáo khoa học: Ras oncogene induces b-galactoside a2,6-sialyltransferase (ST6Gal I) via a RalGEF-mediated signal to its housekeeping promoter
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Several oncogenic proteins are known to influence cellularglycosylation. In particular, transfection of codon 12 pointmutated H-Ras increases CMP-Neu5Ac: Galb1,4GlcNAca2,6-sialyltransferase I (ST6Gal I) activity in rodentfibroblasts. Given that Ras mediates its effects through atleast three secondary effector pathways (Raf, RalGEFs andPI3K) and that transcriptional control ofmouse ST6Gal I isachieved by the selective use of multiple promoters, weattempted to identifywhichof these parameters are involvedin linking the Ras signal to ST6Gal I gene transcription inmouse fibroblasts. ...
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Báo cáo khoa học: Ras oncogene induces b-galactoside a2,6-sialyltransferase (ST6Gal I) via a RalGEF-mediated signal to its housekeeping promoter
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Báo cáo khoa học: Ras oncogene induces b-galactoside a2,6-sialyltransferase (ST6Gal I) via a RalGEF-mediated signal to its housekeeping promoter
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