Báo cáo khoa học: Rational design of a conformation-switchable Ca2+- and Tb3+-binding protein without the use of multiple coupled metal-binding sites
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Ca2+, as a messenger of signal transduction, regulates numerous targetmolecules via Ca2+-induced conformational changes. Investigation into thedeterminants for Ca2+-induced conformational change is often impeded bycooperativity between multiple metal-binding sites or protein oligomeriza-tion in naturally occurring proteins.
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Báo cáo khoa học: Rational design of a conformation-switchable Ca2+- and Tb3+-binding protein without the use of multiple coupled metal-binding sites
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Rational design of a conformation-switchable Ca2+- and Tb3+-binding protein without the use of multiple coupled metal-binding sites
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