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Interaction of cytokines with their cognate receptors leadsto the activation of latent transcription factors, the signaltransducer and activator of transcription (STAT) proteins.Numerous studies have identified the critical roles playedby STAT proteins in regulating cell proliferation, differ-entiation and survival. Consequently, the activity of STATproteins is negatively regulated by a variety of differentmechanisms, which include alternative splicing, covalentmodifications, protein–protein interactions with negativeregulatory proteins and proteolytic processing by pro-teases....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Regulation of STAT signalling by proteolytic processing Lisa Hendry and Susan John
