Báo cáo khoa học: Role of CCP2 of the C4b-binding protein b-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies
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Complement regulator C4b-binding protein (C4BP) and theanticoagulant vitamin K-dependent protein S form a highaffinity complexin human plasma. C4BP is composed ofsevena-chains and a uniqueb-chain, each chain comprisingrepeating complement control protein (CCP) modules. Thebinding site for protein S mainly involves the first of thethreeb-chain CCPs (CCP1). However, recently it has beensuggested that CCP2 of theb-chain also contributes to thebinding of proteinS.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Role of CCP2 of the C4b-binding protein b-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Role of CCP2 of the C4b-binding protein b-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies
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