Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking
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The thyrotropin receptor (TSHR) undergoes a cleavage atthe cell membrane, leading to a heterodimer, comprising anaextracellular and a b-transmembrane and intracellularsubunits, held togetherbydisulfidebonds.Moreover, part ofthe a-subunit of the receptor is shed from thyroid andtransfected L cells.To understand the role of cleavage andshedding, we constructed deletion mutants starting,respectively, at the most N-terminal (S314), and C-terminal(L378) cleavage sites previously mapped, corresponding tofree b1orb2-subunits without further modification ofreceptor structure....
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Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking
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Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking
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