Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction
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The present study aimed to determine the role of Kupffer cells (KCs) incytochrome P450 (CYP) isozyme activity and the expression of its geneduring polymicrobial sepsis. For ablation of KCs, rats were pretreated withgadolinium chloride (GdCl3) at 48 and 24 h before cecal ligation and punc-ture (CLP). The depletion of KCs was confirmed by measuring the mRNAlevel of the KC marker gene CD163.
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Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction
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Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction
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