Báo cáo khoa học: Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription
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Ribonucleotide reductase is essential for the synthesis of allfour dNTPs required for DNA replication. The enzyme iscomposed of two proteins, R1 and R2, which are bothneeded for activity. Expression of the R1 andR2mRNAs isrestricted to the S-phase of the cell cycle, but the R1 andR2promoters shownoobvious sequence homologies that couldindicate coordination of transcription. Here we study initi-ation of transcription at the natural mouse R2 promoter,which contains an atypical TATA-box with the sequenceTTTAAA, using a combination ofin vivo reporter geneassays andin vitrotranscription. ...
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Báo cáo khoa học: Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription
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Báo cáo khoa học: Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription
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