Báo cáo khoa học: Side-chain control of b-peptide secondary structures Design principles
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As one of the most important families of non-natural poly-mers with the propensity to form well-defined secondarystructures, theb-peptides are attracting increasing attention.The compounds incorporatingb-amino acid residues havefound various applications in medicinal chemistry andbiochemistry.The conformational pool ofb-peptides com-prises several periodic folded conformations, which can beclassified as helices, and nonpolar and polar strands.Thelatter two are prone to form pleated sheets.The numerousstudies that have been performed on the side-chaindependence of the stability of the folded structures allowcertain conclusions concerning the principles of design ofthe b-peptide foldamers....
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Báo cáo khoa học: Side-chain control of b-peptide secondary structures Design principles
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Báo cáo khoa học: Side-chain control of b-peptide secondary structures Design principles
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