Báo cáo khoa học: Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor
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Poly(ethylene glycol) (PEG) is a widely used polymer employed to increasethe circulating half-life of proteins in blood and to decrease their immuno-genicity and antigenicity. PEG attaches to free amines, typically at lysineresidues or at the N-terminal amino acid. This lack of selectivity can pres-ent problems when a PEGylated protein therapeutic is being developed,because predictability of activity and manufacturing reproducibility areneeded for regulatory approval.
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Báo cáo khoa học: Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor
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Báo cáo khoa học: Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor
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