Báo cáo khoa học: Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3
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Sequence alignments of human molybdopterin synthase sulfurase, MOCS3,showed that the N-terminal domain is homologous to Escherichia coliMoeB, whereas the C-terminal domain is homologous to rhodanese-likeproteins. Previous studies showed that the activity of the separately purifiedrhodanese-like domain of MOCS3 displayed 1000-fold lower activity incomparison to bovine rhodanese with thiosulfate as sulfur source.
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Báo cáo khoa học: Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3
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